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Faculty and Staff Biography

 
Profile Photo

Cyrielle Billon

Assistant Professor, Pharmacology
Center for Clinical Pharmacology
 

Education

B.S. Genetics and Developmental Biology, University of Lyon 1, Lyon France.

M.S. Genetic and Cell Biology and Pathology, University of Lyon 1, Lyon France.

Ph.D. Genetic and Molecular Biology, ENS of Lyon, Lyon France.

Specialty

Nuclear receptors pharmacology, drug discovery, molecular biology, inflammation, cardiovascular diseases, metabolic disorders, muscle physiology

Current Research

My current research foccus on understanding the role of Estrogen Related Receptors (ERR) in muscle metabolism and metabolic disorders. The ERR family have been desmostrated to control mitochindrial biogenesis, oxidative metabolism and energy expenditure.

I am currently working on understanding the role of ERR in these mechanisms using synthetic ligands developed in the lab.

Other aspect of my research includes undertanding the role of 2 other nuclear receptors, ROR and Rev-Erb, in the regulation of inflammatory disorders and cardiovascular diseases.

My research involves in vivo models of metabolic disorders, cellular and molecular biology, next generation sequencing and bio-informatics.

Vita Highlights

1. Circadian rhythm-dependent and circadian rhythm-independent impacts of the molecular clock on type 3 innate lymphoid cells.

Wang Q, Robinette ML, Billon C, Collins PL, Bando JK, Fachi JL, Sécca C, Porter SI, Saini A, Gilfillan S, Solt LA, Musiek ES, Oltz EM, Burris TP, Colonna M.

Sci Immunol. 2019 Oct 4;4(40). pii: eaay7501. doi: 10.1126/sciimmunol.aay7501.

2. Doubled lifespan and patient-like pathologies in progeria mice fed high-fat diet.

Kreienkamp R*, Billon C*, Bedia-Diaz G, Albert CJ, Toth Z, Butler AA, McBride-Gagyi S, Ford DA, Baldan A, Burris TP, Gonzalo S.

Aging Cell. 2019 Feb;18(1):e12852. doi: 10.1111/acel.12852. Epub 2018 Dec 12.

3. RORγ regulates the NLRP3 inflammasome.

Billon C, Murray MH, Avdagic A, Burris TP.

J Biol Chem. 2019 Jan 4;294(1):10-19. doi: 10.1074/jbc.AC118.002127. Epub 2018 Nov 19.

4. Adropin: An endocrine link between the biological clock and cholesterol homeostasis.

Ghoshal S, Stevens JR, Billon C, Girardet C, Sitaula S, Leon AS, Rao DC, Skinner JS, Rankinen T, Bouchard C, Nuñez MV, Stanhope KL, Howatt DA, Daugherty A, Zhang J, Schuelke M, Weiss EP, Coffey AR, Bennett BJ, Sethupathy P, Burris TP, Havel PJ, Butler AA.

Mol Met, doi.org/10.1016/j.molmet.2017.12.002.

5. Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle

Welch R.D , Billon C, Valfort A-C, Burris T.P, and Flaveny C.A.

Sci Rep. 2017 Dec 7;7(1):17142. doi: 10.1038/s41598-017-17496-7.

6. Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity Of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice.

Pourcet B, Zecchin M, Ferri L, Beauchamp J, Sitaula S, Billon C, Delhaye S, Vanhoutte J, Mayeuf-Louchart A, Thorel Q, Haas J, Eeckhoute J, Dombrowicz D, Duhem C, Boulinguiez A, Lancel S, Sebti Y, Burris T, Staels B, Duez H. Gastroenterology. 2017 Dec 22. pii: S0016-5085(17)36725-2. doi: 10.1053/j.gastro.2017.12.019.

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